Theses/Dissertations from 2013
Developing Generally Applicable Tools to Investigate TetR Family Transcriptional Regulators, Sang Kyun Ahn
INVESTIGATION OF THE STRUCTURAL DETERMINANTS STABILIZING THE OPEN CONFORMATION OF THE CLPP AXIAL CHANNEL, John A. Alexopoulos
COMPARATIVE ANALYSES OF MICROBIAL GENOMES TO IDENTIFY MOLECULAR MARKERS FOR DIFFERENT GROUPS OF PROKARYOTES, Vaibhav Bhandari
CHARACTERIZATION OF BCL-2 INTERACTING PARTNERS AT THE ENDOPLASMIC RETICULUM, Franklin Chan
Huntingtin Nuclear Localization: Current Insights into Mechanism and Regulation, Carly R. Desmond
Cell Death Mechanisms at the Endoplasmic Reticulum, Fei Geng
ELUCIDATING THE ROLE OF THE YJEQ AND RBGA GTPASES IN THE ASSEMBLY OF THE BACTERIAL RIBOSOME, Ahmad Jomaa
DIFFERENTIAL PLURIPOTENT REGULATION DEPENDENT UPON DEFINED FACTORS IN HUMAN INDUCED PLURIPOTENT STEM CELLS, Sarah Laronde
CHARACTERIZATION OF THE OLIGOMERIZATION OF THE HUMAN XRCC4 DNA REPAIR PROTEIN: IMPLICATIONS TO NON-HOMOLOGOUS END JOINING, Wilson KY Lee
Characterization of the Interaction Between Dbf4 and Rad53 During Replication Stress in Budding Yeast, Lindsay A. Matthews
CHARACTERIZING THE FUNCTION AND REGULATORY MECHANISMS OF THE HISTONE DEMETHYLASE KDM5B: INSIGHTS INTO THE COMPLEXITY OF EPIGENETIC REGULATION, Leanne Stalker
SsrB-dependent regulation during Salmonella pathogenesis, Ana M. Tomljenovic-Berube
Theses/Dissertations from 2012
Using Small Molecules to Alter Secondary Metabolism in Streptomyces, Salman Ahmed
INSIGHTS INTO THE DEVELOPMENT OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE: STUDIES FROM GENE TARGETED MICE LACKING THE HIGH DENSITY LIPOPROTEIN RECEPTOR, SR-BI, Aishah Aljarallah Ms.
Investigating the Role of Glycogen Synthase Kinase-3α in the Initiation and Progression of Atherosclerosis, Nicole S. Banko
The ribosomal function and GTPase activity of Escherichia coli EngA, Amrita Bharat
Functional studies of the interstrand cross-link repair protein, SNM1A and its beta-CASP domain, Beverlee D. Buzon
Possible Intrinsic adjuvanticity of the Amb a 1 (Ambrosia artemisiifolia :Ragweed) allergen, Andrew Bysice
The Role of the In Vivo Microenvironment in Human Stem Cell Fate Decisions, Clinton JV Campbell
THE VIRULENCE CHAPERONE NETWORK ASSOCIATED WITH THE SPI-2 ENCODED TYPE THREE SECRETION SYSTEM OF SALMONELLA ENTERICA, Colin Cooper
SMALL MOLECULE INTERROGATION OF S. COELICOLOR GROWTH, DEVELOPMENT AND SECONDARY METABOLISM, Arryn Craney
USING GENE EXPRESSION ANALYSIS TO GUIDE AND IDENTIFY TREATMENTS FOR BREAST CANCER PATIENTS, Robin M. Hallett
EXPLOITING GLYCOPEPTIDE TAILORING ENZYMES AS AN APPROACH TO OVERCOME RESISTANCE, Lindsay R. Kalan
THE CRYO-EM STRUCTURE OF THE ∆RIMM IMMATURE 30S RIBOSOMAL SUBUNIT: A SNAPSHOT OF THE PROTEIN FACTORY UNDER CONSTRUCTION, Meredith C. Kent
Structural and Functional Studies of hAPTX, Refat Arin S. Khan
TOWARDS THE DEVELOPMENT OF A CYTOCHROME C BIOSENSOR, Jennifer A. Lee
Strategies to Investigate the Role of EpCAM in Cancer Stem Cells of Breast Cancer Cell Lines, Ali Lessan
CLONING AND CHARACTERIZATION OF FULL LENGTH GCD AND INTERNAL TRUNCATIONS OF TGCD, Sidi Li
FUNCTION OF YJEE AND RIBOSOME ASSEMBLY FACTORS, Chand S. Mangat
CHARACTERIZATION AND APPLICATION OF SELF-PHOSPHORYLATING DEOXYRIBOZYMES, Simon A. McManus
DECODING TOXICITY: CHARACTERIZATION OF THE IBSC/SIBC TYPE I TOXIN-ANTITOXIN SYSTEM OF ESCHERICHIA COLI, Wendy (Wing Ki) Mok
CHARACTERIZING THE FUNCTION OF HUNTINGTIN IN THE CELL STRESS RESPONSE AS A TARGET FOR DRUG DISCOVERY IN HUNTINGTON’S DISEASE, Lise N. Munsie
Delineating the Role of TCF3 in Mouse Embryonic Stem Cell Self-Renewal and Differentiation, Deborah Ng
THE DEVELOPMENT OF A MODEL SYSTEM FOR THE CHARACTERIZATION OF CANCER STEM CELL PROPERTIES IN BRAIN METASTASES FROM THE LUNG, Sara M. Nolte
Discovery and Characterization of Ibomycin: An Anticryptocccal Metabolite Produced by WAC 2288, Jonathan S. O'Brien
Cis-Regulatory Evolution in Salmonella enterica, Suzanne Osborne
Direct Conversion of Fibroblasts to Hematopoietic Progenitors, Linda Rodriguez
CHARACTERIZING CBID AND BAX BINDING TO SUPPORTED LIPID BILAYERS WITH SINGLE MOLECULE RESOLUTION, Sanjeevan Shivakumar
Properties of Two Enzymes Involved in the Phosphoinositide Cycle – Diacylglycerol Kinase and Phosphatidylinositol 4-Phosphate 5-Kinase, Yulia V. Shulga
ROLE OF THE PSEUDOMONAS AERUGINOSA INNER MEMBRANE PROTEIN PILC IN TYPE IV PILUS FUNCTION, Herlinder K. Takhar
The Type 1 Fimbrial Adhesin Mediates the Interaction of Adherent-Invasive Escherichia coli with the Host, Lauren E. Wallar
A two step mechanism for activation of actinorhodin export and resistance in Streptomyces coelicolor, Ye Xu
Theses/Dissertations from 2011
Functional Structures: The Role of XRCC4 and XLF in Mammalian DNA Double-Strand Break Repair, Sara N. Andres
INVESTIGATION OF ANTIBIOTIC RESISTANCE IN ISOLATED LECHUGUILLA CAVE STRAINS, Kirandeep Bhullar
LENGTHENED G1 PHASE INDICATES DIFFERENTIATION STATUS IN HUMAN EMBRYONIC STEM CELLS., Ashley Calder
STRUCTURAL INSIGHTS INTO THE ROLES OF SEQA ON ORIGIN SEQUESTRATION AND CHROMOSOME ORGANIZATION, Yu Seon Chung
The Engineering of Riboswitch-Based Sensors of Small Molecules in Bacteria and Their Application in the Study of Vitamin B12 Biology, Casey C. Fowler
THEORETICAL STUDY OF STATE-DEPENDENT ACTION OF TOXINS AND DRUGS IN A VOLTAGE GATED SODIUM CHANNEL, Daniel Garden
A HIGH-THROUGHPUT SCREEN TO IDENTIFY SMALL MOLECULES THAT SELECTIVELY TARGET TUMOR-INITIATING CELLS IN A MOUSE MODEL OF HER2-INDUCED BREAST CANCER, Andrew O. Giacomelli
SELECTION OF CELL-INTERNALIZING CIRCULAR DNA APTAMERS, Jimmy Gu
Inhibition of Notch signaling targets breast tumor initiating cells, Maria Kondratyev
CHARACTERIZATION OF A GTP-BINDING DNA APTAMER, Lawrence Lin
Pseudomonas aeruginosa Major Pseudopilin XcpT is Incorporated into The Type IV Pilus Under Native Conditions, Navpreet K. Rana Ms
Uncovering the Antibiotic Kinome with Small Molecules, Tushar Shakya
COMBATING INTRINSIC ANTIBIOTIC RESISTANCE IN GRAM-NEGATIVE BACTERIA, Patricia Taylor
Functional analysis of Pso2 reveals a novel DNA hairpin endonuclease activity: Implications for interstrand crosslink repair, Tracy E. Tiefenbach
THE IDENTIFICATION AND CHARACTERIZATION OF PROTEIN KINASE INHIBITORS TARGETING BREAST CANCER STEM CELLS, Salma Trabelsi
Regulation of macrophage SR-BI by lipoproteins and inflammatory stimuli, David Yu Chang Wang
Characterizing the Stability and Mechanism of Human Mismatch Repair Factor MutLα, Jessica Wong
Theses/Dissertations from 2010
Characterization of Erythromycin Esterases: A Genomic Enzymology Approach to Macrolide Resistance, Kate L. Pengelly
Theses/Dissertations from 2004
INVESTIGATING THE MOLECULAR MECHANISMS OF BCL-2 AND BAX IN THE REGULATION OF APOPTOSIS, Matthew G. Annis
Identification of cell cycle regulatory proteins that interact with HCF-1, David Piluso
Theses/Dissertations from 2003
Saccharomyces cerevisiae aspartate kinase mechanism and inhibition, David Christopher Bareich
Molecular Investigations into the Catalytic Mechanisms and Inhibition of the Aminoglycoside Antibiotic Resistance Enzymes APH(3')-Illa and AAC(6')-APH(2"), David Douglas Boehr
CARRIER MEDIATED LIPID TRANSPORT, Scott D. Covey
CHARACTERIZATION OF AAC(6')-APH(2"), A BIFUNCTIONAL AMINOGLYCOSIDE MODIFYING ENZYME, DENIS M. DAIGLE
Characterization of the Chromosomal Aminoglycoside 6' -N-Acetyltransferase from Enterococcus faecium, Karl-ann Draker
Crystal structure and hydroxyapatite binding of osteocalcin from porcine, Quyen Quoc Hoang
The Targeting Mechanisms and Membrane Topology of Tail-Anchored Proteins, Peter K. Kim
Characterization of the beta-subunit of the mammalian SRP receptor and its role in assembly of the SRP receptor, Kyle R. Legate
Theses/Dissertations from 2002
STRUCTURE AND FUNCTION STUDIES OF MAMMALIAN ADENOSINE KINASE, MARY CHRISTINE MAJ
CHARACTERIZATION OF MEMBRANE-BINDING BY FTSY, THE PROKARYOTE SRP RECEPTOR, Jonathan S. Millman
Protein Kinases in Streptomyces: Involvement in Growth, Glycopeptide Production and Resistance., John Morley Neu
Structure and Function Studies of Hsp47: A Collagen-Specific Molecular Chaperone, Christy A. Thomson
Theses/Dissertations from 2001
Identification of target genes of PEA3, an ETS family transcription factor, Jason Ellison
Theses/Dissertations from 2000
The Structure of Homoserine Dehydrogenase from Saccharomyces cerevisiae, Byron DeLaBerre
Theses/Dissertations from 1999
The modulation of protein kinase C by hydration and membrane spontaneous curvature, Jennifer Giorgione
Characterization of homoserine dehydrogenase from Saccharomyces cerevisiae: An antifungal target, Suzanne Lyne Jacques
Glycopeptide Antibiotic Biosynthesis and Resistance in Streptomyces toyocaensis NRRL 15009, Christopher Gary Marshall
Characterization of aminoglycoside phosphotransferase APH(3')-IIIa, an enterococcal enzyme conferring resistance to aminoglycoside antibiotics, Geoffrey A. McKay
The molecular mechanism of transcriptional activation by the peroxisome proliferator activated-receptor alpha, Kenji Sean Miyata
Theses/Dissertations from 1998
Functional Analysis of the Ninth Subunit of Yeast RNA Polymerase II, RPB9, Sally Anne Hemming
Crystallographic studies on two structures of a kanamycin kinase: a Mg-AMPPNP and a Mg-ADP complex., Wa-Ching Hon
Theses/Dissertations from 1997
Evolutionary studies based on the 70-kDa heat shock family of protein sequences, Mizied Falah
Mechanisms of reparative growth in adult peripheral cutaneous nerves, Sandra Lourenssen
Interactions of class A and class L amphipathic helical peptides with model membranes, Ivan V. Polozov
Theses/Dissertations from 1996
Characterization and phosphorylation site mapping of human pleckstrin, Karen Leigh Craig
EVALUATION OF MANOMETRY AND DEFECOGRAPHY ASSESSMENT FOR CONSTIPATION AND INCONTINENCE, Susan Isobel Shannon
Theses/Dissertations from 1995
Analysis of Loss of Telomeric DNA During Replicative Aging of Human Cells and Examination of the Role of this Process in the Induction of Cell Senescence, Richard Charles Allsopp
Double Layer interaction Model and Particle Concentration Effect in Water, Jianzhong Guo
The Effects of Membrane Physical Properties on Insulin Receptor Autophosphorylation and Signalling, Christine Diane McCallum
Structure/Function Studies of Rat Uncoupling Protein in Yeast Mitochondria, Debra Lynn Murdza-Inglis
Investigation of Protein-Protein and Protein-DNA Interactions Involved in the Function of Herpes Simplex Virus Transactivator Vmw65, Peter Xiao Shaw
Ice Binding Structure and Mechanism of an Antifreeze Protein from Winter Flounder, Frank Sicheri
Cerebral lateralization of dopamine-mediated functions in the rat, Ron Sullivan
Investigation of Regulation of Transfer RNA Gene Expression in Mammalian Cells: Utilization of a Human Nonsense Suppressor Transfer RNA, Richard Ian Tapping