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Theses/Dissertations from 2014

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Investigating the Role of Interleukin-15 in Modulating Adipose Tissue, Nicole G. Barra

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Mechanisms of Th2 Immunity in Peanut Allergic Sensitization, Derek K. Chu

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The Functional Domains of PHLDA1: Modulation of Intracellular Localization Impacts Apoptotic Cell Death, Celeste AF Collins

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The Biology of Dendritic Cell Subsets in Allergen-Induced Asthma, Benny Dua

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CHEMO-PREVENTATIVE EFFECTS OF HYDROGEN SULFIDE-RELEASING NSAIDS IN MURINE COLORECTAL CANCER, Wagdi K. Elsheikh

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AN IN VITRO MODEL TO EVALUATE THE EFFECTS OF ANTICOAGULANTS ON CLOT FORMATION IN THE PRESENCE OF LOW PLATELET COUNTS, Jorell Gantioqui

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THE ROLES OF HEDGEHOG AND AP-2 SIGNALING IN THE REGULATION OF LENS DEVELOPMENT, Christine L. Kerr

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THE ROLE OF STEROL REGULATORY ELEMENT BINDING PROTEIN (SREBP) IN KIDNEY FIBROSIS, Maria Mustafa

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ON THE ORIGIN AND FUNCTION OF WAXING AND WANING IN PACEMAKER ACTIVITY IN THE SMALL INTESTINE, Andrew J. Pawelka

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CYB5D2 Possesses Tumour Suppressing Activities, Yen Ting Shen

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Impact of diet induced obesity on mouse skeletal muscle health: metabolism, growth and regeneration., Karin E. Trajcevski

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A TRI-MODALITY COMPARISON OF VOLUMETRIC BONE MEASURE QUANTIFICATION USING 1.0 TESLA PERIPHERAL MAGNETIC RESONANCE IMAGING, PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY AND HIGH-RESOLUTION-PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY IMAGES, Andy Kin On Wong

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THE EFFECT OF THE ER STRESS INHIBITOR, 4-PHENYLBUTYRATE, ON CHRONIC KIDNEY DISEASE IN A MODEL OF SALT SENSITIVE HYPERTENSION, Victoria Yum

Theses/Dissertations from 2013

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INDUCTION OF NEUROTROPHIC AND DIFFERENTIATION GENES IN NEURAL STEM CELLS BY VALPROIC ACID, Walaa Saeed Almutawaa

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The Role of Periostin in Promoting the Progression of Clear Cell Renal Cell Carcinoma, Nazihah Bakhtyar

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Characterization of the Mechanism of Action for Novel Dopamine D2 Receptor Allosteric Modulators, Dipannita Basu

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EQUIVALENECE OF ANTIBODY BINDING TO HLA ON BEADS AND CELLS: CRITICAL TESTS IN TRANSPLANATION, Balpreet Brar

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CHARACTERIZATION OF CYB5D2 AND ITS HEME BINDING ASSOCIATED FUNCTIONS, Anthony Bruce

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Interactions of a covalently - linked antithrombin-heparin complex with components of the fibrinolytic pathway, Ankush Chander

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Method Development, Feasibility and Clinical Pilot Study of Air Displacement Plethysmography for Longitudinal Body Composition Measurements of Preterm Infants in Hospital, Jennifer Chin

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Lung Immunopathology Following Influenza And Pneumococcus Infection: Mechanisms Of Disease And Therapeutic Approaches, Daniela Damjanovic

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FATTY ACIDS IN NUTRITION SOURCES FOR PRETERM INFANTS, Naomi H. Fink

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MECHANISMS OF TGFβ ACTIVATION IN LUNG FIBROSIS, Aaron Froese

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Regulation of the tumour suppressor PTEN through exosomes, Kathleen Gabriel

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EXPOSURE TO CIGARETTE SMOKE AND ITS IMPACT ON THE OVARIAN FOLLICLE POPULATION: MECHANISMS OF FOLLICLE LOSS, Anne M. Gannon

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INVESTIGATION OF CD36 SCAVENGER TYPE B RECEPTOR EXPRESSING MACROPHAGES IN INTESTINAL INFLAMMATION, Elizabeth Alexandera Garside

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ROLE OF TRANSFORMING GROWTH FACTOR BETA IN PROTEINURIA, Ayesha Ghayur

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THE ROLE OF IL-15 AND NK CELLS IN BREAST TUMOR FORMATION AND METASTASIS, Amy Gillgrass

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TARGETING THE TUMOUR ASSOCIATED ANTIGENS PLAC1 AND GP100 WITH ONCOLYTIC CANCER VACCINES, Stephen J. Hanson

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CHARACTERIZING THE ROLE OF TOLL-LIKE RECEPTOR 2 IN SENSING AND REGULATING HUMAN IMMUNDEFICIENCY VIRUS-1 INFECTION FROM MOTHER-TO-CHILD THROUGH BREAST MILK, Bethany M. Henrick

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NONINVASIVE IMAGING OF LUNG PATHOLOGY AND PHYSIOLOGY IN MURINE MODELS OF ASTHMA AND COPD, Brian N. Jobse

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Comprehensive Metabolomic Analysis in Peanut Sensitization and Peanut-Induced Anaphylaxis: Discovery of Biomarkers and Mediators, Joshua Kong

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The Human Coronavirus Nucleocapsid Protein and Its Effects on the Innate Immune Response, Frances W. Lai

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RELATIONSHIP BETWEEN CD8+ T CELL IMMUNITY AND AGING USING WEST NILE VIRUS INFECTION AS A MODEL, Alina Lelic

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MODELING AND MECHANISTIC INSIGHTS INTO THE DEVELOPMENT OF ALLERGIC AIRWAY RESPONSES TO HOUSE DUST MITE, Alba Llop Guevara

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ADAPTIVE EVENTS IN THE TUMOR LIMIT THE SUCCESS OF CANCER IMMUNOTHERAPY, AJ Robert McGray

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MS-275 (ENTINOSTAT) PROMOTES SUSTAINED TUMOR REGRESSION IN THE CONTEXT OF BOOSTING ONCOLYTIC IMMUNOTHERAPY, Andrew Nguyen

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DOES FOLIC ACID SUPPLEMENTATION PREVENT NICOTINE-INDUCED BETA CELL DYSFUNCTION, Catherine J. Nicholson

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The role of Xin in skeletal muscle regeneration, Aliyah A. Nissar

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CHARACTERIZING THE ACUTE MITOCHONDRIAL RESPONSE TO RESISTANCE EXERCISE IN AGING, Daniel I. Ogborn

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The Assessment of Structural and Material Bone Qualities in Adults with Type 2 Diabetes, Janet M. Pritchard

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Developing Predictive Models For Postnatal Growth Of Preterm Infants During And After Unimpaired Postnatal Adaptation, Preeya Raja

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Influence of maternal atopy and innate and adaptive immune stimuli on cord blood hematopoietic progenitor cells, Pia-Lauren Reece

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LEPTIN IN PREGNANCY: ASSOCIATION WITH BONE HEALTH IN THE OFFSPRING, Dilisha J. Rodrigopulle

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TRUNCATIONS OF THE RESPONSE REGULATOR AGRA INHIBIT STAPHYLOCOCCUS AUREUS QUORUM SENSING, Alexandra L. Ruyter

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CHARACTERIZATION OF A POPULATION OF TUMOUR-INITIATING CELLS WITH STEM-LIKE PROPERTIES IN HUMAN PROSTATE CANCER, Adrian P. Rybak

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β-catenin overexpression within the metanephric mesenchyme causes renal dysplasia via upregulation of the Gdnf signalling axis, Sanjay Sarin

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EFFECTS OF VALPROIC ACID ON EXPRESSION OF THE MELATONIN RECEPTORS MT1 AND MT2, AND THE NEUROTROPHIC FACTORS BDNF AND GDNF IN VIVO, Arani Sathiyapalan

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Applying Phage Display to Screen a Library of α1-Proteinase Inhibitor Mutants for Improved Thrombin Binding Activity, Benjamin M. Scott

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VISCERAL PAIN RESPONSES TO COLORECTAL DISTENTION IN RATS THAT HAVE RECOVERED FROM A BOUT OF COLITIS, Jessica L. Sessenwein

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LUNG-HOMING OF ENDOTHELIAL PROGENITOR CELLS AND ANGIOGENESIS IN ASTHMA: ROLE OF EOSINOPHILS, Nirooya Sivapalan

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THE EFFECTS OF PPAR AGONISTS ON EOSINOPHIL FUNCTION, Steven G. Smith

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Anti-Psychotic Drug Induced Tardive Dyskinesia: A Role for the Anti-Apoptotic Molecule Curcumin, Christal D. R. Sookram

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IMPROVING ONCOLYTIC VESICULAR STOMATITIS VIRUS THROUGH MODULATION OF THE ANTI-TUMOUR IMMUNE RESPONSE, Kyle B. Stephenson

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Inhibition of the prothrombinase complex on phospholipid vesicles, activated platelets, and red blood cells by a covalently-linked antithrombin-heparin complex, Ivan Stevic

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HOPX EXPRESSION IN IMMUNE REGULATORY B CELL REGULATE INTESTINAL INFLAMMATION, Nalayini Thayaparana Nala

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IDENTIFYING FACTORS DRIVING TNF-α EXPRESSION IN THE DUAL CLOSED LOOP EX-VIVO PLACENTAL PERFUSION MODEL: A METHODOLOGICAL STUDY, Tarushika Vasanthan

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The Role of the Transcription Factor Ets-1 in Mitochondrial Metabolism and Oxidative Stress, Meghan L. Verschoor

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STAT3 and SMAD Signaling in Mouse Models of Oncostatin M-Induced Lung Extracellular Matrix Remodeling, Steven Wong

Theses/Dissertations from 2012

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VIRAL-ALLERGEN INTERACTIONS: INSIGHTS INTO THE ORIGINS OF ALLERGIC ASTHMA., Amal Al-Garawi

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THE ROLE OF NEUTROPHILS IN SEVERE ASTHMA, Afia Aziz-ur-Rehman

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CONTRIBUTION OF THE UNFOLDED PROTEIN RESPONSE (UPR) TO ADIPOGENESIS AND WHOLE BODY ENERGY HOMEOSTASIS, Sana Basseri

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Gastrointestinal-Sparing Effects of Novel NSAIDs in Rats with Compromised Mucosal Defence, Rory W. Blackler

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THE ROLE OF INTERFERON REGULATORY FACTOR 3 IN THE INNATE ANTIVIRAL RESPONSE, Tracy Chew

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CHARACTERIZATION OF CHLAMYDIA PNEUMONIAE CDSD AND ITS ROLE IN THE BASAL BODY OF THE TYPE III SECRETION APPARATUS, Robert C. Clayden

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In Silico Modelling of Complex Biological Processes with Applications to Allergic Asthma and Cancer, Marc Colangelo

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Parathyroid hormone-related protein in giant cell tumour of bone, Robert W. Cowan

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The Effect of Goblet Cell Metaplasia On Airway Barrier Integrity, Christopher J. Dalle Ave

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Effects of Extreme Temperature on Airway Smooth Muscle Cell Death, Lindsay E. DoHarris

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Correlates of Mucosal Humoral Immunity in Peripheral Blood, Jason R. Fernandes

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Eukaryotic and Prokaryotic Sources of Colonic Hydrogen Sulfide Synthesis, Kyle L. Flannigan

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ASPECTS OF HUMAN RHINOVIRUS INFECTION IN HOSPITALIZED AND NON-HOSPITALIZED INDIVIDUALS, Andrea C. Granados

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The effect of lifelong maternal obesity on pregnancy outcomes and placental development, Emily K. Hayes

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INVOLVEMENT OF SRC TYROSINE KINASE AND CALCIUM-HANDLING IN AIRWAY SMOOTH MUSCLE EXCITATION-CONTRACTION COUPLING, Brent T. Humber

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Fetal Origin of Chronic Immune Disease: Role of Prenatal Stress Challenge, Caitlin A. Jago

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Targeting gp41 as a strategy to induce mucosal and humoral immunity against HIV-1, Sumiti Jain

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The Effects of Bifidobacterium Longum NCC3001 on AH Neuron Excitability and Slow Wave Activity of the Mouse Intestine, Amir Khoshdel

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Investigation into the Unique Roles of MMP-2 and MMP-9 in TGFβ-Induced Epithelial-Mesenchymal Transition in Lens Epithelial Cells, Anna Korol

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The Impact of Macrophage Polarity and the Tumor Microenvironment on NK Cell Phenotype and Function, Tamara Krneta

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THE ROLE OF GP130 CYTOKINES IL-6 AND OSM ON TUMOR DEVELOPMENT IN MOUSE MODELS FOR LUNG ADENOCARCINOMA, Sean Lauber

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Characterization of CopN (Cpn0324) the Putative Type III Secretion System Plug Protein of Chlamydia pneumoniae, Tiffany L. Leighton

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Procoagulant effects of lung cancer chemotherapy on HUVEC, A549 cells, and monocytes., Zakhar Lysov

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The Regulation of Brain Serotonergic and Dopaminergic Neurons: The Modulatory Effects of Selective Serotonin Reuptake Inhibitors, Atypical Neuroleptics and Environmental Enrichment, Lindsey E.S. MacGillivray

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Impact of Commensal Intestinal Microbiota on Nervous System Development and Function, Karen-Anne McVey Neufeld PhD

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GLUCOSE SUPPLEMENTATION AND MEASURES OF OXIDATIVE STRESS IN PATIENTS WITH GLYCOGEN PHOSPHORYLASE DEFICIENCY (MCARDLE’S DISEASE)., Nicholas Joseph Mocellin

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Investigation of the interaction of multimerin 1 with components of prothrombinase, in vitro, Zainab A. Motala

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The Role of TIM-4 in the Intestinal Inflammation, Natasha Nurtanio

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INVESTIGATION OF THE CYTOPROTECTIVE EFFECTS OF SONIC HEDGEHOG IN CELLULAR AND ANIMAL MODELS OF AMYOTROPHIC LATERAL SCLEROSIS, Randy Peterson

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Evaluation of an early biomarker panel for the identification of emergency department patients at high risk for a short term cardiac outcome, Kim Phan

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The Requirement of Matrix Metalloproteinase 2 and 9 in Transforming Growth Factor Beta Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells, Giuseppe Pino

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Mechanisms Underlying Rhythmic Activities of the Gastrointestinal Tract, Marc J. Pistilli

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ETV5 as a Regulator of Matrix Metalloproteinase 2 in Human Chondrosarcoma, Patricia F. Power

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Mechanisms Underlying the Immunopathology in Heterologous Pulmonary Infection, ELENA PRETUS

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EXAMINING DETERMINANTS OF INSULIN RESISTANCE IN ADULTS BORN AT NORMAL AND EXTREMELY LOW BIRTH WEIGHT, Laura Ramsingh

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Fusing the C-terminal tridecapeptide of hirudin to α1-proteinase inhibitor M358R accelerates its rate of thrombin inhibition, Leigh Ann C. Roddick

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THE ROLE OF AMP-ACTIVATED PROTEIN KINASE (AMPK) IN MEDIATING RADIATION RESPONSES IN CANCER CELLS, Toran Sanli

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The Regulation of Vascular Wall Cells by a TLR Ligand and Gp130 Cytokines, David L.K. Schnittker

CHARACTERIZATION OF CHILDREN AT-RISK FOR DEVELOPING ANXIETY DISORDERS: FINDINGS FROM CLINICAL ASSESSMENTS, BEHAVIOURAL DATA AND FUNCTIONAL MAGNETIC RESONANCE IMAGING, Rhandi Senaratne

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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THE CHLAMYDIA PNEUMONIAE TYPE III SECRETION SYSTEM, Christopher B. Stone

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MOLECULAR RESPONSES OF LUNG CANCER TO IONIZING RADIATION: INVESTIGATION OF THE BIGUANIDE METFORMIN IN COMBINATION WITH IONIZING RADIATION, Yaryna Storozhuk