Author

Pierre Pilon

Date of Award

2-1984

Degree Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

Supervisor

Professor C. J. L. Lock

Abstract

The molecular and crystal structures of platinum complexes relevant to the cancer research field are investigated. The complexes whose structures have been studied, encompass many aspects of the chemistry of platinum(II): the preparation of starting materials, the solvolysis of the complexes in different solvents and the chemistry of the complexes with DNA bases. The important structural features of the complexes are outlined and, where possible, the molecular structures are related to previous information on the complexes which is available from animal studies, solution work or the interaction of the complexes with the DNA macromolecule.

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