Date of Award


Degree Type


Degree Name

Doctor of Philosophy (PhD)




Professor C. J. L. Lock


Interest in technetium chemistry is derived from the fact that it is a recently-discovered element and from the use of technetium-99m as a radioactive label in diagnostic medicine. Compounds related to both sources of interest have been characterized by X-ray crystallography, vibrational spectroscopy and multinuclear nuclear magnet resonance spectroscopy.

The crystal structure of a penicillamine complex of technetium consists of an oxotechnetium(V) core bonded to the S, N, and O atoms of one penicillamine moiety and the S and N atoms of a second. Further characterization, including tracer studies with ⁹⁹ᵐTc, indicate that this complex is identical to an hepatobiliary agent erroneously formulated as a technetium(IV) species. The crystal structure of an anionic catechol complex of technetium also contains the oxotechnetium(V) core and suggests that the technetium(IV) formulation for a number of other radio-pharmaceuticals is incorrect. The crystal structure determination of a complex containing the ethylenebis(2-mercaptoacetamide) ligand forms part of a larger program to design, systematically, new scanning agents.

Technetium complexes involving cyanide ligands are shown to be similar to their rhenium analogs.

Several new technetium(VII) species were synthesized and used to establish ranges for parameters in the nuclear magnetic resonance spectroscopy of ⁹⁹Tc.

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