Date of Award

6-1980

Degree Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Department

Chemistry

Supervisor

Professor C.J.L. Lock

Abstract

A previously unknown mode of binding of platinum complexes to the DNA bases is described. The binding mode is characteristic of cis and not trans-Pt(NH₃)₂Cl₂ and is thought to be related to the ability of cis compounds to form hydroxobridged dimers. It is suggested that the differing anticancer activity of cis and trans-Pt(NH₃)₂Cl₂ may result from this difference in chemistry which is based on the differing stereochemical requirements of cis and trans isomers.

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Chemistry Commons

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