Date of Award
Doctor of Philosophy (PhD)
Professor C.J.L. Lock
A previously unknown mode of binding of platinum complexes to the DNA bases is described. The binding mode is characteristic of cis and not trans-Pt(NH₃)₂Cl₂ and is thought to be related to the ability of cis compounds to form hydroxobridged dimers. It is suggested that the differing anticancer activity of cis and trans-Pt(NH₃)₂Cl₂ may result from this difference in chemistry which is based on the differing stereochemical requirements of cis and trans isomers.
Sporanzini, Robert A., "DNA Base Complexes of Platinum and the Antitumor Action of cis-Pt(NH₃)₂Cl₂" (1980). Open Access Dissertations and Theses. Paper 620.