Date of Award
Master of Science (MSc)
The inheritance of mitochondria and their genomes is predominantly uniparental in plants and animals. However, in fungi, the patterns of inheritance can become complex. Interestingly, in Cryptococcus neoformans, the inheritance pattern is predominantly uniparental. Similar to C. neoformans, closely related Cryptococcus gattii is also a pathogenic fungus, except that it is capable of infecting healthy individuals. In this research, PCR-RFLP was employed on progeny of 14 crosses in order to determine if the mtDNA inheritance pattern is the same in Cryptococcus gattii as was found in C. neoformans. Additionally, the effect of genetic distance between mating partners on mitochondrial inheritance was investigated by using a range of strains across three of the four distinct lineages in C. gattii. My results identified highly variable patterns of inheritance among strains and strain combinations, both within and between the analyzed lineages in C. gattii.
Wilson, Amanda J., "Highly variable mitochondrial inheritance in intra- and inter-lineage crosses of Cryptococcus gattii" (2011). Open Access Dissertations and Theses. Paper 6441.
McMaster University Library
Available for download on Thursday, September 26, 2013