Date of Award
Fall 2012
Degree Type
Thesis
Degree Name
Master of Science (MSc)
Department
Biology
Supervisor
Jonathan Dushoff
Language
English
Committee Member
Brian Golding, Paul Higgs
Abstract
We introduce new software (ISAAC: Improved Structural Annotation of attC) to annotate cassette arrays in bacterial integrons by finding attI and attC sites, and to provide detailed annotation of the attC sites for analysis. We demonstrate an initial application of ISAAC by annotating the cassette complements of all the integrons we identified in the RefSeq bacterial genome database, and providing an analysis of the patterns of nucleotide frequencies at the structurally important positions in the attCs we’ve found.
Recommended Citation
Szamosi, Judith C., "ISAAC: AN IMPROVED STRUCTURAL ANNOTATION OF ATTC AND AN INITIAL APPLICATION THEREOF" (2012). Open Access Dissertations and Theses. Paper 7477.
http://digitalcommons.mcmaster.ca/opendissertations/7477
McMaster University Library