Date of Award
Master of Science (MSc)
Brian Golding, Paul Higgs
We introduce new software (ISAAC: Improved Structural Annotation of attC) to annotate cassette arrays in bacterial integrons by ﬁnding attI and attC sites, and to provide detailed annotation of the attC sites for analysis. We demonstrate an initial application of ISAAC by annotating the cassette complements of all the integrons we identiﬁed in the RefSeq bacterial genome database, and providing an analysis of the patterns of nucleotide frequencies at the structurally important positions in the attCs we’ve found.
Szamosi, Judith C., "ISAAC: AN IMPROVED STRUCTURAL ANNOTATION OF ATTC AND AN INITIAL APPLICATION THEREOF" (2012). Open Access Dissertations and Theses. Paper 7477.
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