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Author

Mary M. Pater

Date of Award

11-1975

Degree Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Department

Biology

Supervisor

Professor Stanley Mak

Abstract

The effect of infection by human adenovirus type 12 on the pre-existing cellular DNA was examined in an abortive system as well as a productive system. The results were discussed in relation to the known effects of infection on chromosomes and the mechanism by which such effects are induced.

The effects of viral infection on certain aspects of DNA replication in human KB cells were also studied. It was observed that the ligation of the "Okazaki fragments" was slower after infection by this virus. It was also observed that the inhibition of cell DNA synthesis by this virus is not a random process and that certain classes of DNA, as distinguished by their high buoyant density and by their high reiteration frequency, was selectively synthesized.

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