Date of Award
11-1975
Degree Type
Thesis
Degree Name
Doctor of Philosophy (PhD)
Department
Biology
Supervisor
Professor Stanley Mak
Abstract
The effect of infection by human adenovirus type 12 on the pre-existing cellular DNA was examined in an abortive system as well as a productive system. The results were discussed in relation to the known effects of infection on chromosomes and the mechanism by which such effects are induced.
The effects of viral infection on certain aspects of DNA replication in human KB cells were also studied. It was observed that the ligation of the "Okazaki fragments" was slower after infection by this virus. It was also observed that the inhibition of cell DNA synthesis by this virus is not a random process and that certain classes of DNA, as distinguished by their high buoyant density and by their high reiteration frequency, was selectively synthesized.
Recommended Citation
Pater, Mary M., "Cellular DNA Metabolism After Infection by Adenovirus Type 12" (1975). Open Access Dissertations and Theses. Paper 847.
http://digitalcommons.mcmaster.ca/opendissertations/847