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Author

Hisanori Ezoe

Date of Award

1-1976

Degree Type

Thesis

Degree Name

Doctor of Philosophy (PhD)

Department

Biology

Supervisor

Professor Stanley Mak

Abstract

Physical and biological properties of a low oncogenic mutant (cyt mutant) of highly oncogenic human adenovirus type 12 were studied. The highly oncogenic parental strain contains much higher proportion of functionally defective particles than the cyt mutant. The role of defective virions was discussed in relation to oncogenicity of the viruses. Correlation of defectivity and viral DNA structure, as studied by electron microscopy, was made. Some defective virions have a specific deletion in their DNA. Also molecular mechanism for the reduction of virus yield by the cyt mutant was examined and it was found that the viral DNA synthesis was a limiting factor.

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Biology Commons

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