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<title>DigitalCommons@McMaster</title>
<copyright>Copyright (c) 2013 McMaster University All rights reserved.</copyright>
<link>http://digitalcommons.mcmaster.ca</link>
<description>Recent documents in DigitalCommons@McMaster</description>
<language>en-us</language>
<lastBuildDate>Wed, 22 May 2013 01:31:15 PDT</lastBuildDate>
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<title>IMMIGRANT SELF-EMPLOYMENT: THE IMPACT OF RESIDENTIAL AND ENTREPRENEURIAL CONCENTRATION, AND EDUCATION ON IMMIGRANT SELF-EMPLOYMENT OUTCOMES</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7798</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7798</guid>
<pubDate>Tue, 21 May 2013 15:43:34 PDT</pubDate>
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	<p>This dissertation investigates the effects of ethnic resources generated by an immigrant group’s concentration in self-employment and a geographic area, and class resources—education in particular—on the self-employment outcomes of immigrant business, which has been a lasting interest from the early days of immigrant entrepreneurship research. To examine the effects of immigrants’ concentration and education, ordinary least squares regression and hierarchical linear regression for cross-classified random effects models are fit to each of the 26 minority and white immigrant groups in the 33 Canadian CMA’s (Census Metropolitan Areas). Using the 2006 Census, the dissertation examines (1) the effects of immigrants’ REC (Residential and Entrepreneurial Concentration) in CMA’s; (2) the interactions between REC and reactive ethnicity—an enhanced awareness of one’s ethnicity due to disadvantage in the host society; and (3) the effects of education on self-employment propensity and income. Unlike previous studies which examined one or a few immigrant or minority groups in one or a few locales, the dissertation provides empirical evidence on the effects of REC and education on self-employment outcomes, based on a wide range of immigrant groups in Canadian CMA’s. The findings indicate that positive effects of REC as well as education on self-employment outcomes exist, but are limited to increasing the self-employment propensity of some immigrant groups. The effects of REC and education on self-employment income, however, are found to be generally insignificant. The study also provides the first empirical evidence that the positive effects of some types of REC become more positive as the reactive ethnicity of an immigrant group increases, as reactive ethnicity theory predicts.</p>

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<author>Jangman Hong</author>


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<title>Predicting Customer Satisfaction from Dental Implants Perception Data</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7797</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7797</guid>
<pubDate>Tue, 21 May 2013 15:43:33 PDT</pubDate>
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	<p>In recent years, measuring customer satisfaction has become one of the key concerns of market research studies. One of the basic features of leading companies is their success in fulfilling their customers’ demands. For that reason, companies attempt to find out what essential factors dominate their customers’ purchasing habits.</p>
<p>Millennium Research Group (MRG) - a global authority on medical tech- nology market intelligence - uses a web-based survey tool to collect informa- tion about customers’ level of satisfaction. One of their surveys is designed to gather information about the practitioner’s level of satisfaction on different brands of dental implants. The Dental Implants dataset obtained from the survey tool has thirty-four attributes, and practitioners were asked to rank or specify their level of satisfaction by assigning a score to each attribute.</p>
<p>The basic question asked by the company was whether the attributes were useful to make customer behavior predictions. The aim of this study is to assess the reliability and accuracy of these measures and to build a model for future predictions, then, determine the attributes that are most influential</p>
<p>in the practitioners’ purchasing decisions. Classification and regression trees (CART) and Partial least squares regression (PLSR) are the two statistical approaches used in this study to build a prediction model for the Dental Implants dataset.</p>
<p>The prediction models generated, using both of the techniques, have rel- atively small prediction powers; which may be perceived as an indication of deficiency in the dataset. However, getting a small prediction power is gener- ally expected in market research studies. The research then attempts to find ways to improve the power of these models to get more accurate results. The model generated by CART analysis tends to have better prediction power and is more suitable for future predictions. Although PLSR provides extremely small prediction power, it helps finding out the most important attributes that influence the practitioners’ purchasing decisions. Improvements in pre- diction are sought by restricting the cases in the data to subsets that show better alignment between predictors and customer purchasing behaviour.</p>

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<author>Omnya Elmassad</author>


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<title>ENVIRONMENTAL IMPACT ASSESSMENTS AND IMPACT BENEFITS AGREEMENTS: THE PARTICIPATION OF ABORIGINAL WOMEN AT VOISEY’S BAY MINE</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7796</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7796</guid>
<pubDate>Tue, 21 May 2013 15:43:31 PDT</pubDate>
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	<p>Resource extraction projects in the North are governed by negotiated agreements developed between industry, the state and Aboriginal governments and institutions. This thesis examines the role played by women in the Environmental Impact Assessment (EIA) and Impact Benefit Agreement (IBA) processes leading up to Voisey’s Bay mine in northern Labrador and whether women’s involvement in resource governance improves the participation and retention of women in non-traditional jobs at the mine. Using a qualitative methodology of semi-structured interviews and thematic analysis, this thesis found that the participation of Aboriginal women was unable to significantly improve the work experiences of women at the mine. The concerns of Aboriginal women were identified by analyzing submissions made to the EIA panel by women’s groups. These concerns were then compared with the perceptions of work by women who worked in either construction or the operations phase of the mine. The confidentiality of IBA negotiations and documents are offered as one reason that Aboriginal women did not have the concerns they raised during the EIA process mitigated. The unfinished IBA was referred to by VBNC, and accepted by the panel, as a way to mitigate women’s concerns despite confidentiality preventing the contents of the IBA from ever being known. While women received prioritization in the IBA, Aboriginal women demanded quotas and targets for the training and hiring of women for the construction and operations phase. The thesis ends with a discussion of ways to alleviate the conflict between IBA and EIA processes.</p>

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<author>David J. Cox</author>


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<title>The Effects of Acute and Chronic Hypoxia on Muscle Metabolism in Mice</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7795</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7795</guid>
<pubDate>Tue, 21 May 2013 15:43:29 PDT</pubDate>
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	<p>Under hypoxia mammals face many challenges, especially in terms of energy production. To conserve O2, mammals may enter a hypometabolic state or rely more heavily on anaerobic metabolism. However, the latter strategy is not a viable option during chronic hypoxia and other cellular changes are needed. Under chronic hypoxia, mammals have been predicted to alter their metabolic machinery in an attempt to increase the efficiency of ATP production to reduce the amount of O2 used by the mitochondria. One way efficiency is believed to increase is through a change in the composition of cytochrome c oxidase (COX). Cell culture experiments have shown a decrease in the COX4-1 isoform and an increase in the COX4-2 isoform under hypoxia, leading to an increase in the reaction efficiency of COX. In the present study, I observed an increase in the mRNA levels of COX4-2 after 24hrs of hypoxia. However, this change was not mirrored by corresponding changes at the protein level. Further, I examined the phosphorylation state of pyruvate dehydrogenase (PDH) as an indicator of PDH activity. Under chronic hypoxia resting mice exhibited a significant rise in PDH phosphorylation. This increase may represent a decrease in PDH activity and a decreased reliance on carbohydrate derived acetyl-CoA.</p>
<p>I also explored the effects plastic changes in muscle during chronic hypoxia had on muscle metabolism during acute exercise. In hypoxic post-exercise mice, a significant increase in muscle lactate levels was observed compared to rest. This rise was not present in control mice, suggesting that acclimated mice were relying more heavily on anaerobic metabolism. However, there were no significant changes in PDH phosphorylation in post-exercise mice which could help to explain elevated muscle lactate levels.</p>

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<author>Alex D. Connaty Mr.</author>


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<title>IS KIN RECOGNITION IN CAKILE EDENTULA AFFECTED BY NUTRIENT AVAILABILITY?</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7794</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7794</guid>
<pubDate>Tue, 21 May 2013 15:43:26 PDT</pubDate>
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	<p><strong>ABSTRACT</strong></p>
<p>As plants are sessile organisms, detecting the presence of neighboring plants and exhibiting competitive behavior to acquire limiting resources is crucial. One of the ways plants respond to belowground competition is by allocation to fine roots in order to acquire the limited resources. However, this phenotypic plasticity can be costly as it assigns resources away from reproduction. Being able to recognize the relatedness of one′s neighbours and preferentially compete with strangers is a beneficial trait that can minimize the costs of competition with relatives and increases inclusive fitness. Many studies have looked at the association between resource availability and competition in plants while others have observed kin recognition in several plants species. However, no one has yet studied the effect of resource availability on kin recognition in plants. Here, I looked at root architecture to test if there is an association between kin recognition and nutrient availability in <em>Cakile edentula</em>.</p>
<p>I found that the root system architecture is highly plastic and complex, showing variable responses to neighbour identity signals and resource availability. The results from the four experiments demonstrate that the responses of <em>C. edentula </em>to neighbour relatedness are dependent on nutrient availability. Additionally, this study also indicates that kin recognition in <em>C. edentula</em> does not require root contact; instead it occurs through a signal found in soluble compounds excreted from plants, possibly root exudates, as observed in <em>Arabidopsis thaliana</em> <em>(</em>Biedrzycki et al. 2010).</p>
<p>In conclusion, this study provides novel findings regarding the dynamics of root behavior in response to nutrient availability and the relatedness of neighbours.</p>

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<author>Mudra Bhatt</author>


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<title>COMPARATIVE ANALYSES OF MICROBIAL GENOMES TO IDENTIFY MOLECULAR MARKERS FOR DIFFERENT GROUPS OF PROKARYOTES</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7793</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7793</guid>
<pubDate>Tue, 21 May 2013 15:43:24 PDT</pubDate>
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	<p>Currently centered on molecular data, bacterial and archaeal relationships are often based on their relative branching in 16S rRNA based phylogenetic trees. The availability of numerous bacterial genome sequences over the past two decades has provided new information for insights previously inaccessible to the field of taxonomy. Through utilization of comparative genomics, numerous molecular markers in the form of insertions and deletions within conserved regions of proteins, also known as Conserved Signature Indels or CSIs, have been discovered for various prokaryotic taxa. Using these techniques, we have analyzed relationships among the bacterial phyla of Thermotogae and Synergistetes and the conglomeration of bacterial organisms known as the PVC super-phylum. Through identification of large numbers of CSIs we have described the phyla Thermotogae and Synergistetes, and their sub-groups, in molecular terms for the first time. The identified molecular markers support a reconstruction of the current taxonomic divisions of these phyla. Similarly, previously only observed to group in phylogenetic trees, we have identified molecular markers for the PVC clade of bacterial phyla which are indicative of their shared ancestry. Further, in response to recent suggestions of extensive lateral gene transfer masking evolutionary relationships, an argument in favour of Darwinian mode of evolution for prokaryotic organisms is made using the identified molecular markers identified here along with markers previously identified in similar studies. Due to their taxonomic specificity, the markers that we have discovered provide useful tools for biochemical tests aiming for an understanding of the unique characteristics of the bacterial groups to which they are specific.</p>

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<author>Vaibhav Bhandari</author>


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<title>Investigating Minimally Invasive Stressors for Functional MRI of the Kidneys</title>
<link>http://digitalcommons.mcmaster.ca/opendissertations/7792</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/opendissertations/7792</guid>
<pubDate>Tue, 21 May 2013 15:43:23 PDT</pubDate>
<description>
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	<p>Chronic kidney disease (CKD) has an annual mortality rate of 22% and can cause secondary complications including hypertension, anemia, secondary hyperparathyroidism, and malnutrition. Currently, clinical diagnosis and evaluation of CKD involves blood and urine testing and biopsy. MRI is not currently used to image CKD, but there is an interest in developing MRI techniques to test kidney function. Usually, renal functional MRI refers to single images reflecting tissue oxygenation. Using time series information may offer additional information about changes in kidneys as a result of disease. In this thesis, blood oxygen level-dependent (BOLD) MRI and diffusion weighted imaging (DWI) were used to investigate the effects of breath holding and water loading on kidneys. First, BOLD MRI was used to measure effects of breath holding on BOLD signal intensity. DWI and fractal analysis were used to measure changes in diffusion, perfusion and microcirculation shortly after water loading. Breath holding results showed no effect on temporal BOLD signal intensity in young, healthy subjects. A significant decrease in signal intensity was measured in the kidney of a single subject with impaired renal function. Although the renal BOLD signal was found to have fractal characteristics, no changes were measured using this technique between pre- and post-water loading scans during the time period examined. Because the signal appears to behave fractally, this technique may be a good candidate for similar kidney function studies in the future. DWI also remained unchanged as a result of water loading during the post-water loading time period examined.</p>

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<author>Marla A. Shaver</author>


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<title>Material Consequence and Counter-Factuals</title>
<link>http://digitalcommons.mcmaster.ca/philosophy_coll/3</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/philosophy_coll/3</guid>
<pubDate>Mon, 20 May 2013 16:20:12 PDT</pubDate>
<description>
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	<p>A conclusion is a “material consequence” of reasons if it follows necessarily from them in accordance with a valid form of argument with content. The corresponding universal generalization of the argument’s associated conditional must be true, must be a covering generalization, and must be true of counter-factual instances. But it need not be law-like. Pearl’s structural model semantics is easier to apply to such counter-factual instances than Lewis’s closest-worlds semantics, and gives intuitively correct results.</p>

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<author>David Hitchcock</author>


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<title>Donner l’élan nécessaire à l&apos;utilisation de l&apos;indicateur de mortalité évitable au Canada</title>
<link>http://digitalcommons.mcmaster.ca/mhf_issue-briefs/17</link>
<guid isPermaLink="true">http://digitalcommons.mcmaster.ca/mhf_issue-briefs/17</guid>
<pubDate>Wed, 15 May 2013 07:28:43 PDT</pubDate>
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<author>Lebei Pi et al.</author>


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